Urology News Feeds

Virtual tissue technology reveals new drug target in polycystic kidney disease

MedicalNewsToday - Wed, 06/29/2016 - 02:00
Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.
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The Impact of Diabetes Mellitus and Obesity on Artificial Urinary Sphincter Outcomes in Men

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
To evaluate the impact of diabetes and obesity on artificial urinary sphincter (AUS) outcomes.
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Occurrence of and Risk Factors for Urological Intervention during Benign Hysterectomy – Analysis of the National Surgical Quality Improvement Program Database

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
To determine the occurrence of lower genito-urinary tract (LGUT) injury during hysterectomy for benign disease and identify risk factors for LGUT injury, with a specific focus on the effect of hysterectomy modality.
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Antegrade Sclerotherapy to Treat All Types of Varicoceles in the Paediatric Population: Experience of a Single Centre.

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
To analyse our experience with antegrade sclerotherapy for the treatment of Coolsaet type I, II and III varicoceles in a paediatric and adolescent population.
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Temporal Trends in Conduit Urinary Diversion with Concomitant Cystectomy for Benign Indications: a Population-Based Analysis

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
To describe national trends in cystectomy at the time of urinary diversion for benign indications. Multiple practice patterns exist regarding the necessity of concomitant cystectomy with urinary diversion for benign end-stage lower urinary tract dysfunction. Beyond single institution reports, limited data is available to describe how concurrent cystectomy is employed on a national level.
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A Systematic Review of Ileal Conduit and Neobladder Outcomes in Primary Bladder Cancer

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
Treatment for MIBC with curative intent includes radical cystectomy and urinary diversion. Using PRISMA guidelines, we conducted a systematic review assessing differences in patient selection, operative parameters, complications and quality of life between ileal conduit and neobladder cohorts. Ileal conduit cohorts have more advanced age and disease, more co-morbidities and complications, and poorer quality of life. Ileal conduit surgery is associated with adverse patient selection that inhibits reasonable comparison of outcomes with neobladder cohorts.
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Editorial Comment

Nocturia in the absence of diurnal complaints is typically due to nonurological causes such as NP, often in association with SAS. Urologists can evaluate for NP via a simple voiding diary and in such cases SAS should be considered.
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Author Reply

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
We thank the editorialists for their comments regarding our manuscript assessing perioperative complications for patients undergoing radical nephrectomy in the presence of disseminated cancer.1 As the editorial correctly points out, the role and sequencing of cytoreductive nephrectomy with targeted therapy is an outstanding issue and remains to be addressed in ongoing clinical trials. The introduction of immune checkpoint inhibition for renal cell carcinoma may further muddy these waters.
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Editorial Comment

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
Surgical cytoreduction has been an integral component of multimodal therapy for metastatic renal cell carcinoma (mRCC) since the seminal reports supporting cytoreductive nephrectomy (CN) were published.1,2 With the introduction and adoption of targeted therapies and increasing enthusiasm for checkpoint inhibition, the role and sequential timing of CN are now the source of considerable debate. Given the emerging data associating CN with significant perioperative morbidity, critical consideration of optimal patient selection remains paramount.
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Erratum

Urology (Gold Journal) In Press - Wed, 06/29/2016 - 00:00
In the Editorial Comment by Thomas Allen Gardner, Clinton D. Bahler, and Paul T. Gellhaus to the August 2015 article “Analysis of Renal Functional Outcomes After Radical or Partial Nephrectomy for Renal Masses ≥7 cm Using the RENAL Score” (Urology 2015;85:319-320), the commenting editors regret that the commenting editor name Paul T. Gellhaus was misspelled.
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Re: Update on Lasers in Urology. Current Assessment on Holmium:yttrium-aluminum-garnet (Ho:YAG) Laser Lithotripter Settings and Laser Fibers

Footnotes

Department of Urology, SLK Kliniken Heilbronn, Heilbronn, Germany

Corresponding author. Department of Urology, SLK Kliniken Heilbronn, Am Gesundbrunnen 20–24, 74076 Heilbronn, Germany.

Article information

PII: S0302-2838(16)30344-X
DOI: 10.1016/j.eururo.2016.06.026
© 2016 Published by Elsevier B.V.

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Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

Abstract Context

Bladder cancer has become a common cancer globally, with an estimated 430 000 new cases diagnosed in 2012.

Objective

We examine the most recent global bladder cancer incidence and mortality patterns and trends, the current understanding of the aetiology of the disease, and specific issues that may influence the registration and reporting of bladder cancer.

Evidence acquisition

Global bladder cancer incidence and mortality statistics are based on data from the International Agency for Research on Cancer and the World Health Organisation (Cancer Incidence in Five Continents, GLOBOCAN, and the World Health Organisation Mortality).

Evidence synthesis

Bladder cancer ranks as the ninth most frequently-diagnosed cancer worldwide, with the highest incidence rates observed in men in Southern and Western Europe, North America, as well in certain countries in Northern Africa or Western Asia. Incidence rates are consistently lower in women than men, although sex differences varied greatly between countries. Diverging incidence trends were also observed by sex in many countries, with stabilising or declining rates in men but some increasing trends seen for women. Bladder cancer ranks 13th in terms of deaths ranks, with mortality rates decreasing particularly in the most developed countries; the exceptions are countries undergoing rapid economic transition, including in Central and South America, some central, southern, and eastern European countries, and the Baltic countries.

Conclusions

The observed patterns and trends of bladder cancer incidence worldwide appear to reflect the prevalence of tobacco smoking, although infection with Schistosoma haematobium and other risk factors are major causes in selected populations. Differences in coding and registration practices need to be considered when comparing bladder cancer statistics geographically or over time.

Patient summary

The main risk factor for bladder cancer is tobacco smoking. The observed patterns and trends of bladder cancer incidence worldwide appear to reflect the prevalence of tobacco smoking.

Take Home Message

Diverging patterns in bladder cancer are observed linked to the phase of the tobacco epidemic, and in specific countries, the prevalence of Schistosoma haematobium infection. While other factors contribute, harmonisation of registry coding of noninvasive tumours will improve international comparability.

Keywords: Bladder, Cancer, Statistics, Incidence, Mortality.

Footnotes

a Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

b Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, USA

Corresponding author. Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France. Tel. +33 4 72 73 84 53; Fax: +33 4 72 73 86 96.

Article information

PII: S0302-2838(16)30280-9
DOI: 10.1016/j.eururo.2016.06.010
© 2016 European Association of Urology, Published by Elsevier B.V.

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Re: Magnetic Resonance Imaging-Ultrasound Fusion Targeted Prostate Biopsy in a Consecutive Cohort of Men with No Previous Biopsy: Reduction of Over Detection Through Improved Risk Stratification

Footnotes

Department of Urology, Acıbadem University Kadıköy Hospital, Istanbul, Turkey

Corresponding author. Department of Urology, Acıbadem University Kadıköy Hospital, Kadıköy, Istanbul, 34660, Turkey.

Article information

PII: S0302-2838(16)30349-9
DOI: 10.1016/j.eururo.2016.06.031
© 2016 Published by Elsevier B.V.

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IU study finds testicular cancer survivors may have hearing loss after cisplatin therapy

MedicalNewsToday - Tue, 06/28/2016 - 09:00
Many testicular cancer survivors experience hearing loss after cisplatin-based chemotherapy, according to researchers at Indiana University.The researchers, led by Lois B. Travis, M.D., Sc.D.
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Editorial Comment

This systematic review provides a meta-analysis of the literature on the management of clinically localized renal masses with a focus on the comparative effectiveness of radical nephrectomy, partial nephrectomy, thermal ablation and active surveillance. The study was funded by AHRQ and conducted by the Evidence-Based Practice Center at Johns Hopkins. Major findings include an increased incidence of local recurrence after thermal ablation, although equivalence with other treatment modalities was observed when secondary ablations were considered.
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Editorial Comment

This study stands out as authoritative among the reviews on this topic by virtue of the rigorous AHRQ process that is characterized by a major focus on transparency, a methodologically rigorous approach to rating the strength of evidence and strict conflict of interest management that guards against biased interpretation. These characteristics are noteworthy since other SRs are frequently methodologically deficient. Corbyons et al found that SRs published in the urological literature during 2009 to 2012 on average met less than half of the so-called AMSTAR (Assessing the Methodological Quality of Systematic Reviews) criteria that describe the conduct of a high quality SR.
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Surgical Management of Hair-Coil Penile Injury: Anatomical Insights and Grading System

Urology (Gold Journal) In Press - Tue, 06/28/2016 - 00:00
to report our experience in the surgical management of a group of patients with varying degrees of hair-coil penile injury, while applying a more detailed grading scale for the severity of injury.
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Renal Branch Artery Stenosis: a Diagnostic Challenge? A Case Report with Review of the Literature

Urology (Gold Journal) In Press - Tue, 06/28/2016 - 00:00
Renovascular hypertension is a common cause of pediatric hypertension. In the fraction of cases that are unrelated to syndromes such as neurofibromatosis, patients with a solitary stenosis on a branch of the renal artery are common and can be diagnostically challenging. Imaging techniques that perform well in the diagnosis of main renal artery stenosis may fall short when it comes to branch artery stenosis. We report two cases that illustrate these difficulties and show that a branch artery stenosis may be overlooked even by the gold standard method, renal angiography.
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