Urology News Feeds

National underutilization of preemptive and early kidney transplants

MedicalNewsToday - 6 hours 26 min ago
A kidney transplant is a life-changing and life-saving procedure. Yet, a new study conducted by Mayo Clinic and the University of Michigan shows that only one-third of patients who ultimately...
Categories: Urology News Feeds

More evidence that "metabolically healthy obesity" is not a harmless condition

MedicalNewsToday - 13 hours 26 min ago
According to a study published in Annals of Internal Medicine, patients who are overweight or obese, even in the absence of metabolic abnormalities, are at increased risk for chronic kidney disease...
Categories: Urology News Feeds

Uterine Prolapse: Causes, Symptoms and Treatment

MedicalNewsToday - 16 hours 26 min ago
Learn about uterine prolapse, a condition that occurs when the pelvic floor muscles are no longer strong enough to support the uterus correctly.
Categories: Urology News Feeds

Critical Analysis of the Use of Uroflowmetry for Urethral Stricture Disease Surveillance

Urology (Gold Journal) In Press - 18 hours 26 min ago
To critically evaluate the use of uroflowmetry (UF) in a large urethral stricture disease cohort as a means to monitor for stricture recurrence.
Categories: Urology News Feeds

Patterns of Care for Newly Diagnosed Benign Prostatic Hyperplasia in the United States

To examine diagnostic tests and treatment patterns in men with new onset benign prostatic hyperplasia (BPH) using consolidated national electronic health record (EHR) data.
Categories: Urology News Feeds

The relationship between intolerance of uncertainty and anxiety in men on active surveillance for prostate cancer

Anxiety may serve as a major barrier to participation in AS. Intolerance of uncertainty—the tendency to perceive the potential for negative events as threatening—has been linked to cancer-related worry. Accordingly, we explored prospectively the relationship of intolerance of uncertainty with anxiety along with other clinical factors among men managed with AS for prostate cancer.
Categories: Urology News Feeds

Difference in PSA testing among urologist and primary care physician visits

MedicalNewsToday - Mon, 02/08/2016 - 10:00
Declines in prostate-specific antigen (PSA) testing differed among urologist and primary care physician visits in a study that compared testing before and after a 2011 recommendation from the U.S.
Categories: Urology News Feeds

Removal of complex renal tumors performed safely by robotic surgery in selected patients

MedicalNewsToday - Mon, 02/08/2016 - 06:00
Renal cell carcinoma can sometimes spread to the inferior vena cava (IVC), the body's largest vein, posing a threat to the heart and brain.
Categories: Urology News Feeds

Re: Long-Term Changes in Renal Function Outcomes following Radical Cystectomy and Urinary Diversion

M. Nishikawa, H. Miyake, M. Yamashita, T. A. Inoue and M. Fujisawa
Categories: Urology News Feeds

Re: Recurrence Patterns after Open and Robot-Assisted Radical Cystectomy for Bladder Cancer

D. P. Nguyen, A. Al Hussein, B. Awamlh, X. Wu, P. O’Malley, I. M. Inoyatov, A. Ayangbesan, B. M. Faltas, P. J. Christos and D. S. Scherr
Categories: Urology News Feeds

Systemic inflammatory response syndrome after percutaneous nephrolithotomy: A randomized single-blind clinical trial evaluating impact of irrigation pressure

To evaluate the impact of intra-operative irrigation pressures on the risk of developing systemic inflammatory response following percutaneous nephrolithotomy (PCNL)
Categories: Urology News Feeds

The Role of Magnetic Resonance Imaging in Prostate Cancer: Focusing on What Really Matters

Refers to article:

Role of Magnetic Resonance Imaging in Prostate Cancer Screening: A Pilot Study Within the Göteborg Randomised Screening Trial

Anna Grenabo Bergdahl, Ulrica Wilderäng, Gunnar Aus, Sigrid Carlsson, Jan-Erik Damber, Maria Frånlund, Kjell Geterud, Ali Khatami, Andreas Socratous, Johan Stranne, Mikael Hellström and Jonas Hugosson

Accepted 7 December 2015

Footnotes

a Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

b Life Sciences Mathematics Unit, Technische Universität München, Munich, Germany

Corresponding author. Zentrum Mathematik, Technische Universität München, Boltzmannstrasse 3, 85747 Garching, Germany. Tel. +49 89 28918388; Fax: +49 89 28918435.

Article information

PII: S0302-2838(16)00158-5
DOI: 10.1016/j.eururo.2016.01.039
© 2016 European Association of Urology, Published by Elsevier B.V.

Categories: Urology News Feeds

Treatment Effects of WST11 Vascular Targeted Photodynamic Therapy in Urothelial Cell Carcinoma and Feasibility, Safety, and Long Term Outcomes in the Upper Urinary Tract of Swine

Surgical management of upper tract urothelial carcinoma requires removal of kidney and ureter, compromising renal function. Non-surgical alternatives have potentially prohibitive safety concerns. We examine the feasibility and safety of ablation of the ureter and renal pelvis using endoluminal vascular-targeted photodynamic therapy in a porcine model and report efficacy of WST11 vascular-targeted photodynamic therapy in a murine model.
Categories: Urology News Feeds

Role of Protease-Activated Receptor 2 in the development of lower urinary tract dysfunction

Lower urinary tract symptoms are a common finding in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We reported that the mast cell-tryptase-PAR2 axis plays a critical role in the development of chronic pain in experimental autoimmune prostatitis (EAP), a mouse model of CP/CPPS. We therefore examined whether PAR2 activation mediates lower urinary tract dysfunction.
Categories: Urology News Feeds

Comparison of Perioperative and Early Oncologic Outcomes Between Open and Robotic-Assisted Laparoscopic Prostatectomy in a Contemporary Population-Based Cohort

To compare rates of positive surgical margins (PSM), use of postoperative radiation therapy (RT), and perioperative outcomes between robotic-assisted laparoscopic (RALP) and open radical prostatectomy (ORP) in a contemporary population-based cohort.
Categories: Urology News Feeds

Radiation Therapy Versus Radical Prostatectomy: A Never-ending Discussion

Refers to article:

Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis

Christopher J.D. Wallis, Refik Saskin, Richard Choo, Sender Herschorn, Ronald T. Kodama, Raj Satkunasivam, Prakesh S. Shah, Cyril Danjoux and Robert K. Nam

Accepted 10 November 2015

Footnotes

a Department of Urology, Bern University Hospital, Bern, Switzerland

b Department of Radiation Oncology, Bern University Hospital, Bern, Switzerland

c University Clinics Saint Luc, Catholic University of Louvain, Brussels, Belgium

Corresponding author. Department of Urology, Bern University Hospital, Anna Seiler-Haus, Bern 3010, Switzerland. Tel. +41 79 9184982; Fax: +41 31 6323620.

Article information

PII: S0302-2838(16)00168-8
DOI: 10.1016/j.eururo.2016.01.049
© 2016 European Association of Urology, Published by Elsevier B.V.

Categories: Urology News Feeds

A Specific Mapping Study Using Fluorescence Sentinel Lymph Node Detection in Patients with Intermediate- and High-risk Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection

Abstract

Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermediate- and high-risk patients undergoing radical prostatectomy and extended pelvic lymph node dissection. A total of 42 patients received systematic or specific ICG injections into the prostate base, the midportion, the apex, the left lobe, or the right lobe. We found (1) that external and internal iliac regions encompass the majority of SLNs, (2) that common iliac regions contain up to 22% of all SLNs, (3) that a prostatic lobe can drain into the contralateral group of pelvic lymph nodes, and (4) that the fossa of Marcille also receives significant drainage. Among the 12 patients who received systematic ICG injections, 5 (42%) had a total of 29 lymph node metastases. Of these, 16 nodes were ICG positive, yielding 55% sensitivity. The complex drainage pattern of the prostate and the low sensitivity of ICG for the detection of lymph node metastases reported in our study highlight the difficulties related to the implementation of SNL techniques in prostate cancer.

Patient summary

There is controversy about how extensive lymph node dissection (LND) should be during prostatectomy. We investigated the lymphatic drainage of the prostate and whether sentinel node fluorescence techniques would be useful to detect node metastases. We found that the drainage pattern is complex and that the sentinel node technique is not able to replace extended pelvic LND.

Take Home Message

Fluorescence detection of the lymphatic landing sites of the prostate demonstrates a complex drainage pattern, suggesting that lymph node metastases do not follow a predefined pathway of metastatic spread. Our study also shows that the sensitivity of this technique to detect metastases is low.

Keywords: Indocyanine green, Lymphadenectomy, Prostate cancer, Sentinel lymph node, Mapping.

Footnotes

a Department of Urology, Bern University Hospital, Bern, Switzerland

b Institute of Pathology, Bern University Hospital, Bern, Switzerland

Corresponding author. Department of Urology, Bern University Hospital, CH-3010 Bern, Switzerland. Tel. +41 31 632 36 64; Fax: +41 31 632 21 80.

Both authors contributed equally.

Article information

PII: S0302-2838(16)00136-6
DOI: 10.1016/j.eururo.2016.01.034
© 2016 Published by Elsevier B.V.

Categories: Urology News Feeds

Racial disparities in kidney transplant outcomes are narrowing

MedicalNewsToday - Fri, 02/05/2016 - 02:00
A new study reveals significantly reduced disparities in health outcomes among black and white kidney transplant recipients over the past 2 decades.
Categories: Urology News Feeds