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ZS Pharma announces publication of results from phase 3 study of ZS-9 in patients with hyperkalemia

MedicalNewsToday - 13 hours 40 min ago
ZS Pharma have announced the publication of previously unreleased detailed results from the ZS003 study in the New England Journal of Medicine (NEJM).
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The Correct Sequence of Intravesical Chemotherapy and Bacillus Calmette-Guérin for Non–Muscle-invasive Bladder Cancer

Refers to article:

Sequential Combination of Mitomycin C Plus Bacillus Calmette-Guérin (BCG) Is More Effective but More Toxic Than BCG Alone in Patients with Non–Muscle-invasive Bladder Cancer in Intermediate- and High-risk Patients: Final Outcome of CUETO 93009, a Randomized Prospective Trial

Eduardo Solsona, Rosario Madero, Venancio Chantada, Jesus M. Fernandez, Juan A. Zabala, José A. Portillo, Jose M. Alonso, Ander Astobieta, Miguel Unda, Luis Martinez-Piñeiro, Mariano Rabadan, Antonio Ojea, Jesus Rodriguez-Molina, Pastora Beardo, Pedro Muntañola, Matias Gomez, Manuel Montesinos and Jose A. Martinez Piñeiro members of Club Urológico Español de Tratamiento Oncológico.

Accepted 18 September 2014

Footnotes

Department of Urology, Ghent University Hospital, Ghent, Belgium

Corresponding author. Department of Urology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Tel. +32 93322284; Fax: +32 93323889.

Article information

PII: S0302-2838(14)01210-X
DOI: 10.1016/j.eururo.2014.11.028
© 2014 European Association of Urology, Published by Elsevier B.V.

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High potassium levels reduced in chronic kidney disease patients by investigational drug

MedicalNewsToday - Tue, 2014-11-25 03:00
Research just published found that the investigational drug patiromer decreased high potassium levels and maintained normal potassium levels in patients with chronic kidney disease.
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Rare stem cells identified that give rise to chronic tissue scarring

MedicalNewsToday - Tue, 2014-11-25 02:00
Harvard Stem Cell Institute scientists at Brigham and Women's Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood...
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Pleiotropy in Aggressive Prostate Cancer?

Refers to article:

A Genome-wide Pleiotropy Scan for Prostate Cancer Risk

Orestis A. Panagiotou, Ruth C. Travis, Daniele Campa, Sonja I. Berndt, Sara Lindstrom, Peter Kraft, Fredrick R. Schumacher, Afshan Siddiq, Stefania I. Papatheodorou, Janet L. Stanford, Demetrius Albanes, Jarmo Virtamo, Stephanie J. Weinstein, W. Ryan Diver, Susan M. Gapstur, Victoria L. Stevens, Heiner Boeing, H. Bas Bueno-de-Mesquita, Aurelio Barricarte Gurrea, Rudolf Kaaks, Kay-Tee Khaw, Vittorio Krogh, Kim Overvad, Elio Riboli, Dimitrios Trichopoulos, Edward Giovannucci, Meir Stampfer, Christopher Haiman, Brian Henderson, Loic Le Marchand, J. Michael Gaziano, David J. Hunter, Stella Koutros, Meredith Yeager and Robert N. Hoover The PRACTICAL Consortium. Stephen J. Chanock, Sholom Wacholder, Timothy J. Key and Konstantinos K. Tsilidis

Accepted 13 September 2014

Footnotes

Department of Oncology, University of Sheffield, Sheffield, UK

University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. Tel. +44 114 2712373, +44 114 2711692.

Article information

PII: S0302-2838(14)01211-1
DOI: 10.1016/j.eururo.2014.11.029
© 2014 European Association of Urology, Published by Elsevier B.V.

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Living organ donors who need a transplant prioritized in the U.S.

MedicalNewsToday - Mon, 2014-11-24 03:00
In 2010, a total of 16,900 kidney transplants took place in the U.S. Of those, only 6,278 were from living donors.
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Reply by Authors

We absolutely agree that long-term studies of patients with hypospadias should describe sexual function. We have collected these data in our cohort, and they will be reported in a future study.
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Editorial Comment

We realize that our surgery should be judged based on not only short-term results, but also what happens when the child grows. Although cosmesis is the main indication for surgery in patients with distal hypospadias,1 in those with the more severe forms it is function that has to be rendered normal. Urinary function is usually normal preoperatively and should remain so afterward. It is sexual function that must benefit most from this surgery. Chordee must be corrected, and patients should have normal ejaculation and a penile appearance that they deem normal enough to engage in a sexual relationship.
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Editorial Comment

The authors performed a meta-analysis of clinical trials published to date addressing the use of antibiotic prophylaxis in children identified with VUR. The 2 series with the least degree of bias (PRIVENT and RIVUR), also the largest studies, demonstrated a decrease in the incidence of symptomatic UTI. There was no reduction in the incidence of renal scarring.
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Pregnant women who have donated a kidney are at increased risk for hypertension, preeclampsia

MedicalNewsToday - Sun, 2014-11-23 02:00
Nearly 30,000 people become living kidney donors worldwide each year, and many are young women.
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MRI-guided transurethral ultrasound prostate ablation; a pre-clinical safety and feasibility study with 28-day follow-up

To determine the safety and feasibility of MRI-guided transurethral ultrasound prostate ablation using active temperature feedback control in a pre-clinical canine model with 28-day follow-up.
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Mortality After Radical Cystectomy: The Impact of Obesity Versus Adiposity After Adjusting for Skeletal Muscle Wasting

To assess the impact of obesity as measured conventionally by body mass index (BMI) compared to excess adiposity as measured by fat-mass index (FMI) on mortality, following radical cystectomy for bladder cancer, adjusting for the presence of skeletal muscle wasting.
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Targeting the Mechanisms of Progression in Castration-resistant Prostate Cancer

Refers to article:

Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level

Theodoros Karantanos, Christopher P. Evans, Bertrand Tombal, Timothy C. Thompson, Rodolfo Montironi and William B. Isaacs

Accepted 25 September 2014

Footnotes

Lund University, Department of Clinical Sciences, Division of Urological Research, Skåne University Hospital, Malmö, Sweden

Lund University, Department of Clinical Sciences, Division of Urological Research, Jan Waldenströms gata 35, CRC 91:10, Skåne University Hospital, SE20502 Malmö, Sweden. Tel. +46 (0)40391128.

Article information

PII: S0302-2838(14)01198-1
DOI: 10.1016/j.eururo.2014.11.024
© 2014 European Association of Urology, Published by Elsevier B.V.

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Differences in Treatment and Outcome After Treatment with Curative Intent in the Screening and Control Arms of the ERSPC Rotterdam

Abstract

Screening for prostate cancer (PCa) results in a favorable stage shift. However, even if screening did not result in a clinically apparent lower stage or grade, it might still lead to less disease recurrence after treatment with curative intent (radical prostatectomy [RP] and radiation therapy [RT]) because the tumor had less time to develop outside the prostate. The outcome after treatment could also differ because of variations in treatment quality (eg, radiation dosage/adjuvant hormonal therapy). To test these hypotheses, we compared differences in the treatment quality of the screening and control arms of the European Randomized Study of Screening for Prostate Cancer (ERSPC) Rotterdam and disease-free survival (DFS) after curative treatment in PCa patients with similar stage and grade. A total of 2595 men were initially treated with RP or RT. In the control arm, RT was more often combined with hormonal therapy; treatment dosage was often ≥69 Gy. This most likely resulted from changes over time in treatment that coincided with the later detection in the control arm. DFS was higher in the screening arm in all risk groups. After correction for lead time, these differences were minimal, however. We concluded that treatment quality differed between the screening and control arms of the ERSPC Rotterdam. RT quality was especially superior in the control arm with higher dosages and more often RT in combination with hormonal therapy. Despite these differences favoring the control arm, DFS differences were minimal.

Patient summary

We looked at differences in prostate cancer (PCa) treatment and outcome after PCa treatment in men diagnosed after screening and men diagnosed after normal clinical practice. Treatment differed with superior treatment given to men diagnosed in normal clinical practice. We propose a likely explanation for this apparently counterintuitive finding (progressive insight combined with, on average, a later detection of tumors in unscreened men). Although unscreened men received better treatment, this advantage seemed to be outweighed by the advantage associated with the earlier detection, on average, of the tumor in screened men.

Trial registration

ISRCTN49127736

Take Home Message

The quality of similar treatments differed between the screening and control arms of the ERSPC Rotterdam, most likely related to later detection in the control arm and progressive insight. Radiation therapy (RT) quality was especially superior in the control arm with higher dosages, and RT was more often performed in combination with hormonal therapy.

Keywords: Prostatic neoplasms, Prostate-specific antigen, Screening, Radical prostatectomy, Radiotherapy, Cure rates.

Footnotes

a Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands

b Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands

c Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands

Corresponding author. Erasmus University Medical Centre, Department of Urology, Room NA-1710, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Tel. +31 10 703 2243; Fax: +31 10 703 5315.

Article information

PII: S0302-2838(14)01016-1
DOI: 10.1016/j.eururo.2014.10.008
© 2014 European Association of Urology, Published by Elsevier B.V.

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A combination of 2 existing anti-cancer drugs for kidney cancer shows good patient response

MedicalNewsToday - Fri, 2014-11-21 02:00
Researchers have found that patients with an advanced form of kidney cancer, for which there is no standard treatment and a very poor prognosis, respond well to a combination of two existing...
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Ferroptosis, a novel form of non-apoptotic cell death, holds great therapeutic potential

MedicalNewsToday - Fri, 2014-11-21 02:00
Ferroptosis is a newly discovered form of cell death believed to be involved in numerous pathological processes.
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Genetic Polymorphisms in ESR1 and ESR2 Genes and Risk of Hypospadias in a Multi-ethnic Study Population

Estrogenic endocrine disruptors acting via estrogen receptors α (ESR1) and β (ESR2) have been implicated in the etiology of hypospadias, a common congenital malformation of male external genitalia. Our objective was to determine the association of single nucleotide polymorphisms (SNPs) in ESR1 and ESR2 genes with hypospadias in a racially-ethnically diverse study population of California births.
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Reply from Authors re: Sigrid V. Carlsson, Peter C. Albertsen. Better Survival After Curative Treatment for Screen-detected Prostate Cancer Compared with Clinical Diagnosis: A Real Effect or Lead-time Bias? Eur Urol. In press. http://dx.doi.org/10.1016/j.

Refers to article:

Better Survival After Curative Treatment for Screen-detected Prostate Cancer Compared with Clinical Diagnosis: A Real Effect or Lead-time Bias?

Sigrid V. Carlsson and Peter C. Albertsen

Refers to article:

Differences in Treatment and Outcome After Treatment with Curative Intent in the Screening and Control Arms of the ERSPC Rotterdam

Leonard P. Bokhorst, Ries Kranse, Lionne D.F. Venderbos, Jolanda W. Salman, Geert J.L.H. van Leenders, Fritz H. Schröder, Chris H. Bangma and Monique J. Roobol for the ERSPC Rotterdam Study Group.

Accepted 4 October 2014

Footnotes

a Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands

b Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands

Corresponding author. Erasmus University Medical Centre, Department of Urology, Room NA-1710, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Tel. +31 10 703 2243; Fax: +31 10 703 5315.

Article information

PII: S0302-2838(14)01190-7
DOI: 10.1016/j.eururo.2014.11.016
© 2014 European Association of Urology, Published by Elsevier B.V.

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Bipolar versus monopolar transurethral resection of the prostate: A prospective randomized trial focussing on bleeding complications

To compare monopolar versus bipolar transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH) focussing on functional outcome, and rates of bleeding complications and TURP syndrome.
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