Urology News Feeds
To evaluate whether the practice of procedure-time overlapping surgery (OS) is associated with inferior outcomes compared to non-overlapping surgery (NOS) in urology, to address the paucity of data surrounding urologic surgeries to support or refute this practice.
PTEN Hamartoma-Tumor-Syndrome (PHTS) describes a series of conditions characterized by germline-mutation of the PTEN tumor-suppressor gene. PHTS patients have an increased lifetime risk of multiple malignancies, including thyroid, breast, and endometrial cancers. PHTS patients also have 20-30 fold increased risk of renal cell carcinoma (RCC) compared to age-matched controls. As with many hereditary RCC syndromes, tumors present early and multifocally. We present a case of one of the youngest patients diagnosed with RCC in PHTS and review the urologic implications of this syndrome.
To evaluate patient-specific and perioperative factors that may be predictive of bladder perforation during midurethral sling placement.
To quantify the yearly prostate cancer incidence per 100,000 men, comparing consecutive years from 2010 through 2016. In the years immediately following the 2011/2012 U.S. Preventive Services Task Force update to prostate specific antigen (PSA) screening guidelines, PSA screening, biopsy, and subsequent prostate cancer diagnosis and definitive local treatment have declined. We performed an analysis of stage and grade at diagnosis for prostate cancer in the US, in the years following the 2011/2012 update.
Holmium Laser Enucleation of Prostate Within 6 Weeks of Transrectal Ultrasound Guided Prostate Biopsy is Safe and Effective
To evaluate the safety and efficacy of performing Holmium laser enucleation of the prostate (HoLEP) for the treatment of bladder outlet obstruction secondary to an enlarged prostate within 6-weeks of a transrectal ultrasound (TRUS) guided prostate biopsy.
Single-Incision Midurethral Sling by the Dynamic Intraoperative Standing Sling Technique as an Office-Based Procedure: A Pilot Study
To assess the safety, feasibility, and short-term success of placing Solyx™ (Boston Scientific, Marlborough, MA) single-incision midurethral sling (SIMUS) using the Dynamic Intraoperative Standing Sling Technique (DISST©) in an office setting under local anesthesia.
Contemporary Assessment of the Most Cited Clinical, Basic Science, and Guidelines Papers in Urology: A Reference for Urology Journal Club
To perform bibliometric analysis of the top cited articles in urology as a guide for journal club article selection.
Cost effectiveness of sacral neuromodulation and OnabotulinumtoxinA in managing refractory idiopathic overactive bladder
Little information from clinical and modelled studies are available on cost-effectiveness of OnabotulinumtoxinA (BTX) and sacral neuromodulation (SNM) for the treatment of idiopathic overactive bladder (OAB). We aimed to summarise the evidence in this regard from different healthcare systems. Seven studies from 5 countries were reviewed. Some modelled studies with a 10-year time frame showed that SNM became dominant long-term; others suggested BTX was more cost effective at <5 years. There was considerable heterogeneity in the base case / sensitivity analysis and statistical modelling amongst the studies.
Influence of body mass index on the surgical outcomes of flexible ureteroscopy for pediatric upper urinary tract calculi—a single surgeon experience
To examine the association between body mass index (BMI) and surgical outcomes of flexible ureteroscopy (FURS) for pediatric upper urinary tract calculi and to estimate the influence of BMI percentile on the learning curve of pediatric FURS.
To describe incidence and variables associated with venous thromboembolism (VTE) after robot-assisted radical cystectomy (RARC).
Characteristics Associated with Depression, Anxiety, and Social Isolation in Adults with Spina Bifida
To identify demographic and clinical characteristics associated with depression, anxiety, and social isolation among adults with spina bifida. We hypothesize that lower urinary tract dysfunction is associated with poor psychosocial outcomes.
A 13 and 16-year old genetically XY patients presented to a tertiary care facility for gender affirmation. Impending onset and/or progression of puberty prompted patients to seek hormonal therapy. After discussion of fertility preservation options with patients and parents, the 13-year-old underwent testicular biopsy while the 16-year old opted for semen sample. Both patients had success and their genetic material was cryopreserved for future assisted reproduction.Gender affirming procedures and hormone therapy affect the long-term reproductive potential of transgender individuals.
RE: Validating the Martini Staging System for Rectourethral Fistula: A Meta-Analysis of Postoperative Outcomes
We read with great interest the study by Mishra et al.1 on the validation of a staging system for recto-urethral fistulas following radical prostatectomy that we previously published2.
Generalizability of prostate-specific antigen (PSA) screening trials in a “real world” setting: a nationwide survey analysis
The Prostate, Lung, Colorectal and Ovarian cancer (PLCO) and the European Randomized Study of Screening for Prostate Cancer (ERSPC) trials 1,2 have been widely used to inform policy decisions regarding prostate-specific antigen (PSA) screening in the US. However, the generalizability of any trial to its intended population is directly contingent on the study subjects being ‘representative’ of the ‘universe’ (i.e. US men without symptoms or known diagnosis of prostate cancer [PCa]). In the context of PSA screening, its efficacy and effectiveness is predicated upon age, ethnicity and family history of PCa (amongst other factors).
Inflammatory Myofibroblastic Tumor After Treatment of Wilms Tumor in a 6-Year-Old Boy: A Case Report and Literature Review
Inflammatory myofibroblastic tumor (IMT) is a rare tumor with an indolent course. It is less often reported as a second tumor that occurs after treatment of malignant tumors in pediatric patients. Here we report a case of IMT following Wilms tumor (WT), and conduct a literature review concerning IMTs and WT to evaluate the diagnostic possibility of IMT as a second tumor. The co-existence of the two tumors may cause confusion as to whether they share genetic links or that IMTs may appear as late effects of the treatment of WT.
Author Reply to Letter-to-the-Editor on: Validating the Martini Staging System for Rectourethral Fistula
We appreciate the commentary by Martini et al. on our article on the validation of their rectourethral fistula (RUF) staging system. The commentary brings to light many core concepts that we raised in our manuscript.1,2 The first of which is the limitation of the staging system. We fully agree with the commentary that RUF is a complex pathology that cannot be fully captured by a single staging system which is comprehensive enough to account for the multitude of etiologies that lead to RUF. In fact, the authors elucidate that their staging system is primarily meant for post-prostate cancer treatment.
Implementation of Post-operative Standard Opioid Prescribing Schedules Reduces Opioid Prescriptions Without Change in Patient-Reported Pain Outcomes
To implement Standard Opioid Prescribing Schedules (SOPS) based on opioid use following urologic surgeries and to evaluate how evidence-based prescribing schedules affect opioid use and patient reported outcomes.
A 4Kscore cut-off of 7.5% for prostate biopsy decisions provides high sensitivity and negative predictive value for significant prostate cancer.
To evaluate the 4Kscore test's low risk cut off of 7.5% as the indication to proceed with a prostate biopsy by combining data from two independent prospective multicentre trials in the United States which have validated the 4Kscore test as a continuous score to predict clinically significant prostate cancer.
The COVID-19 disease is spreading rapidly worldwide, and no vaccine or very effective drug has been found yet. However, the transmission rate of the disease can be reduced by taking precautions. Therefore, it is essential to detect the patients early to prevent the spread of the disease 1,2. We report a case of 26 year old male patient who was admitted to our urology outpatient clinic with the complaint of flank pain and had incidental findings of COVID-19 in the lung bases on abdominal CT.
We thank the author for their interest in our manuscript and acknowledge the mostly linear growth of female urology residents over the past twelve years based on Accreditation Council for Graduate Medical Education (ACGME) data.1 We acknowledge that our assumption of continued 25% of residents being female could be an underestimate; however, that estimate is derived from the best available data.