Urology News Feeds
“Histopathological Evaluation of the Effects of Intraurethral Platelet Rich Plasma in Urethral Trauma Experimentally Induced in Rat Model” Letter to the Editor
We are happy to answer some of the questions you asked. PRP is a blood component used in regenerative medicine with limited use in urology and there are few studies about this topic. We hope the present study fills a gap in the literature and acts as a guide for different studies at advanced level.
Letter to the editor: Histopathological Evaluation of the Effects of Intraurethral Platelet Rich Plasma in Urethral Trauma Experimentally Induced in Rat Model
We read with great interest the article by Aydın et al. in a recent issue of the journal (Volume 141, July 2020, Pages 187.e9-187.e14).1 The study mentioned above investigated the therapeutic potential of intraurethral platelet-rich plasma (PRP) therapy for preventing inflammation and spongiofibrosis in experimentally induced urethral trauma in the rat model. As the authors stated, PRP used in the study had a platelet count of ∼2 × 106/mm3.1 It was interesting to note that the authors described the main therapeutic component used in the study based on platelet count alone.
Primary extragonadal germ cell tumor (GCT) is a rare but well described entity, the common sites being retroperitoneum or mediastinum. GCTs are further classified as seminomatous and nonseminomatous GCTs, with extragonadal GCTs more likely to be seminomas. Primary seminoma arising in the prostate is extremely rare, and only seven similar cases have been reported in the medical literature. We present this unusual case of a middle aged male with complaints of severe lower urinary tract symptoms (LUTS).
Native Ureter Ventriculo-Ureteral Shunt Placement for Management of Refractory Hydrocephalus in a Child with a History of Renal Transplant: Case Report and Technical Note
This report describes the case of a 5-year-old male with intractable hydrocephalus secondary to neonatal intraventricular hemorrhage who was ultimately managed with the placement of a ventriculo-ureteral (VU) shunt. He had previously failed numerous attempts at cerebrospinal fluid shunting, choroid plexus cauterization, and endoscopic third ventriculostomy. The patient had a history of end stage renal disease, and had previously undergone renal transplant. In an operation that involved Neurosurgeons, Pediatric Urologists, and Transplant surgeons, a Gibson incision was used to avoid the patient's multiple intraabdominal adhesions, and his nonfunctioning renal unit was used to implant a VU shunt without early or late complications.
Prostate Cancer Risk and Prognostic Influence Among Users of 5-Alpha-Reductase Inhibitors and Alpha-Blockers: A Systematic Review and Meta-Analysis
We systematically assessed the effect of 5-alpha-reductase inhibitors (5-ARIs) and/or alpha-blockers use on prostate cancer (PCa) incidence and outcomes, including PCa pathologic progression, PCa-specific mortality, and all-cause mortality. 5-ARIs but not alpha-blockers decreased risk of overall PCa, low grade PCa (Gleason < 7), and delayed PCa pathologic progression. Both 5-ARIs and alpha-blockers had no significant impact on risk of high grade PCa (Gleason ≥ 7), PCa–specific mortality, or all-cause mortality.
While gynecologic malignancy is uncommon in women with conditions such as pelvic organ prolapse and bladder cancer, urologists should be acquainted with the relevant gynecologic literature as it pertains to their surgical care of female patients. While taking the patient history, urologists should be aware of prior cervical cancer screening and ask about vaginal bleeding, which can be a sign of uterine cancer. Urologic surgeons should also discuss the role of concomitant prophylactic oophorectomy and/or salpingectomy for ovarian cancer risk reduction at the time of pelvic surgery.
To evaluate the effect of laparoscopic percutaneous extraperitoneal closure (LPEC) of the internal inguinal ring for the treatment in pediatric abdominoscrotal hydrocele (ASH) and to assess the feasibility and safety of the procedures.
We present a case of 26-year female who presented with acute urinary retention and vulvar mass. She denies any urinary complaints in the past except for occasional straining for voiding. Imaging revealed a prolapsed ureterocele, it was successfully managed with incision and excising a flap of ureterocele due to the risk of postoperative protrusion of the redundant ureterocele. On follow-up at 6 months she was voiding well without any complaints.
The feasibility and impact of a pre-surgical exercise intervention program (prehabilitation) for patients undergoing cystectomy for bladder cancer
To assess the feasibility of a prehabilitation program for cystectomy patients and to determine the effectiveness of the program in improving strength and functional capacity in the peri-operative period.
Lymphatic ascites after pelvic lymphadenectomy is a rare complication and is rarely reported after urologic surgery. We report a case of delayed and refractory lymphatic ascites following robotic assisted laparoscopic radical prostatectomy.
Strangulated internal hernia beneath the obturator nerve after laparoscopic radical cystectomy with extended pelvic lymph node dissection
Internal hernia beneath the vascular structures after pelvic lymphadenectomy is a rare condition. Herein, we report a case of a strangulated internal hernia beneath the obturator nerve 38 months after laparoscopic radical cystectomy with extended pelvic lymphadenectomy. Computed tomography revealed dilated small bowels and a closed loop in the pelvis. The emergency laparotomy was performed, and a strangulated internal hernia beneath the obturator nerve was observed. It is necessary to consider the possibility of internal hernia beneath the vascular structure, including the obturator nerve, after the pelvic lymph lymphadenectomy, particularly via a minimally invasive approach.
Association between Stress Urinary Incontinence and the Components of Metabolic Syndrome among Females 20-59 years
To assess the relationship between stress urinary incontinence (SUI) and metabolic syndrome among a population-based cohort of women 20-59 years.
: To determine the QI experiences of urology residents in the United States.
Reappraisal of the definition criteria for "Genitourinary Syndrome of Menopause", and its effect on quality of life in Turkish postmenopausal women
: To reappraise the definition of Genitourinary syndrome of menopause (GSM) and to evaluate the prevalence and effect of GSM on quality of life in Turkish postmenopausal women.
To share our experience and techniques of robot assisted repair of complex vesico-vaginal fistulae.
A Clinical Reminder Order Check (CROC) Intervention to Improve Guideline-Concordant Imaging Practices for men with Prostate Cancer: A Pilot Study
To understand how to potentially improve inappropriate prostate cancer imaging rates we used National Comprehensive Cancer Network's (NCCN) guidelines to design and implement a Clinical Reminder Order Check (CROC) that alerts ordering providers of potentially inappropriate imaging orders in real-time based on patient features of men diagnosed with low-risk prostate cancer.
RAS/MAPK Pathway Driver Alterations Are Significantly Associated with Oncogenic KIT Mutations in Germ-cell Tumors
To report the mutational profile and clinical outcomes of a cohort of patients with KIT-mutant germ-cell tumors (GCTs).
Clear cell renal cell carcinoma is associated with calcium deposition in a significant percentage of patients. However, frank ossification within a tumor is extremely rare. We report a case of a 41-year-old male with a slow-growing left renal mass who underwent minimally invasive nephron-sparing surgery. Final pathology revealed clear cell renal cell carcinoma with focal areas of heterotopic bone formation. While prognostic implications of this variant are unclear, patients with renal cell carcinoma with osseous metaplasia can present with slow growth kinetics and early-stage disease.
Single-stage Simultaneous Retrograde and Antegrade Endoscopic Treatment of Giant Prostatic and Bladder Urethral Calculi
Calculi encountered in the lower urinary tract typically reside within the bladder, less often in the urethra. In this video, we present a minimally invasive endoscopic approach for removal of the largest total stone volume in the lower urinary tract reported in the literature to date.
Diagnostic accuracy of multiparametric MRI for local staging of bladder cancer: A systematic review and meta-analysis
To evaluate diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) for local staging of urothelial bladder carcinoma (UBC), a systematic review was performed. Of 2369 records, 20 studies met the inclusion criteria (n=1724). We found a pooled sensitivity and specificity for differentiating between stages ≤T1 and ≥T2 of 0.92 (95% CI 0.88-0.95) and 0.88 (95% CI 0.78-0.94). mpMRI shows high sensitivity and specificity for the differentiation between non-muscle invasive and muscle invasive bladder cancer, but does not appear to be useful for staging per T-stage.